From:Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
- Modulation of transcription factors or nuclear receptors that control expression of enzymes involved in CSF formation |
Molecular targets: p73, foxJ1, and E2F5 [30, 31] |
- Interference with the basolateral and apical membrane-associated ion translocaters (cotransporters, exchangers and pumps) |
Molecular targets: Na-K-Cl cotransporter [45–48]; Na-H exchanger [36–38]; Cl-HCO3exchanger [40, 55]; Na pump [49, 106, 107, 110] Na-HCO3cotransporter [41]; Na-dependent Cl-HCO3exchanger [42] K and anion channels in apical membrane [68] |
- Inhibition of the enzymatic generation of labile ions in cytoplasm and in microdomains of the plasma membrane |
Molecular targets: carbonic anhydrase isoforms [43, 44, 52, 53, 56–58] |
- Regulation of the expression and activity of aquaporin water-conducting channels in the apical (CSF-facing) plasma membrane |
Molecular target: Aquaporin 1 channel [65–68, 70–78, 292] |
- Stimulation of plasma membrane receptors for fluid-regulating neuropeptides |
Molecular targets: V1 receptor [83, 84, 90, 207, 210, 217]; NPR receptors [85, 97, 101, 103]; AT1 receptor [217] |