Patient category |
||||||||
---|---|---|---|---|---|---|---|---|
REF |
PC |
AC |
SIH |
IIH |
iNPH |
Comm. HC |
Non-comm. HC |
|
Number of subjects |
28 |
13 |
14 |
14 |
15 |
63 |
11 |
3 |
T1/2, abs(h) |
4.57 ± 3.31 (72%) |
4.12 ± 2.14 (52%) |
4.86 ± 2.93 (60%) |
3.79 ± 2.91 (77%) |
2.32 ± 1.61b(69%) |
4.15 ± 3.07 (74%) |
4.62 ± 3.86 (84%) |
4.92 ± 3.88 (79%) |
Tmax(h) |
7.49 ± 4.09 (55%) |
9.00 ± 4.27 (47%) |
8.89 ± 2.98 (34%) |
7.09 ± 3.44 (49%) |
5.8 ± 2.01 (35%) |
9.85 ± 5.4a(55%) |
8.14 ± 3.44 (42%) |
12.33 ± 7.17 (58%) |
Cmax(μM) |
0.70 ± 0.38 (54%) |
0.66 ± 0.31 (47%) |
0.55 ± 0.23 (42%) |
0.90 ± 0.58 (64%) |
0.83 ± 0.27 (33%) |
0.67 ± 0.48 (72%) |
0.50 ± 0.17a(34%) |
0.54 ± 0.49 (91%) |
Tlag(h) |
0.74 ± 0.67 (91%) |
1.20 ± 0.59a(49%) |
0.74 ± 0.42 (57%) |
1.03 ± 0.89 (86%) |
0.88 ± 0.55 (62%) |
1.16 ± 0.77a (66%) |
1.12 ± 0.87 (78%) |
0.96 ± 0.82 (85%) |
AUC0-∞(μM h) |
12.58 ± 2.55 (20%) |
15.05 ± 3.96 (26%) |
13.65 ± 6.13 (45%) |
15.36 ± 5.92 (39%) |
15.67 ± 4.54a (29%) |
18.49 ± 8.24c (45%) |
12.79 ± 4.68 (37%) |
13.44 ± 3.6 (27%) |