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  1. 检测脉动的脑脊液的变化beplay靠谱(CSF) flow may assist clinical management decisions, but spinal CSF flow is relatively understudied. Traumatic spinal cord injuries (SCI) often cause spinal c...

    Authors: Madeleine Amy Bessen, Christine Diana Gayen, Ryan David Quarrington, Angela Catherine Walls, Anna Victoria Leonard, Vartan Kurtcuoglu and Claire Frances Jones
    Citation: Fluids and Barriers of the CNS202320:5
    Content type:Research Published on:

  3. The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The worksh...

    Authors: 杰森·k . Karimy杰西c . Newville卡梅隆Sadegh, Jill A. Morris, Edwin S. Monuki, David D. Limbrick Jr., James P. McAllister II, Jenna E. Koschnitzky, Maria K. Lehtinen and Lauren L. Jantzie
    Citation: Fluids and Barriers of the CNS202320:4
    Content type:Review Published on:

  4. Impaired cerebrospinal fluid (CSF) homeostasis is central to the pathogenesis of idiopathic intracranial hypertension (IIH), although the precise mechanisms involved are still not completely understood. The ai...

    Authors: Sinah Engel, Johannes Halcour, Erik Ellwardt, Timo Uphaus, Falk Steffen, Frauke Zipp, Stefan Bittner and Felix Luessi
    Citation: Fluids and Barriers of the CNS202320:3
    Content type:Research Published on:

  5. The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood–brain barrier constitute an important ...

    Authors: Simone S. E. Nielsen, Mikkel R. Holst, Kristine Langthaler, Sarah Christine Christensen, Elisabeth Helena Bruun, Birger Brodin and Morten S. Nielsen
    Citation: Fluids and Barriers of the CNS202320:2
    Content type:Research Published on:

    TheCorrection to this articlehas been published inFluids and Barriers of the CNS202320:48

  6. Our previous study demonstrated that M1 macrophages could impair tight junctions (TJs) between vascular endothelial cells by secreting interleukin-6 (IL-6) after spinal cord injury (SCI). Tocilizumab, as a hum...

    Authors: Yang Luo, Fei Yao, Yi Shi, Zhenyu Zhu, Zhaoming Xiao, Xingyu You, Yanchang Liu, Shuisheng Yu, Dasheng Tian, Li Cheng, Meige Zheng and Juehua Jing
    Citation: Fluids and Barriers of the CNS202320:1
    Content type:Research Published on:

  7. Despite the great potential of FUS-BBB disruption (FUS-BBBD), it is still controversial whether FUS-BBBD acts as an inducing factor of neuro-inflammation or not, and the biological responses after FUS-BBBD tri...

    Authors: Hyo Jin Choi, Mun Han, Hyeon Seo, Chan Yuk Park, Eun-Hee Lee and Juyoung Park
    Citation: Fluids and Barriers of the CNS202219:103
    Content type:Research Published on:

  8. In patients with central nervous system (CNS) infections identification of the causative pathogen is important for treatment. Metagenomic next-generation sequencing techniques are increasingly being applied to...

    Authors: Cormac M. Kinsella, Arthur W. D. Edridge, Ingeborg E. van Zeggeren, Martin Deijs, Diederik van de Beek, Matthijs C. Brouwer and Lia van der Hoek
    Citation: Fluids and Barriers of the CNS202219:102
    Content type:Research Published on:

  9. beplay靠谱脑脊液(CSF)是一个重要的和致命一击ical component of the central nervous system (CNS). According to the concept of the “third circulation” originally proposed by Cushing, CSF is mainly produced ...

    Authors: Guojun Liu, Antonio Ladrón-de-Guevara, Yara Izhiman, Maiken Nedergaard and Ting Du
    Citation: Fluids and Barriers of the CNS202219:101
    Content type:Review Published on:

  10. Cervical blood and cerebrospinal fluid (CSF) flow rates can be quantified with Phase-contrast (PC) MRI, which is routinely used for clinical studies. Previous MRI studies showed that venous and CSF flow altera...

    Authors: Maria Marcella Laganà, Sonia Di Tella, Francesca Ferrari, Laura Pelizzari, Marta Cazzoli, Noam Alperin, Ning Jin, Domenico Zacà, Giuseppe Baselli and Francesca Baglio
    Citation: Fluids and Barriers of the CNS202219:100
    Content type:Research Published on:

  11. Treatment with amyloid-β (Aβ) targeting antibodies is a promising approach to remove Aβ brain pathology in Alzheimer's disease (AD) and possibly even slow down or stop progression of the disease. One of the ma...

    Authors: Ulrika Julku, Mengfei Xiong, Elin Wik, Sahar Roshanbin, Dag Sehlin and Stina Syvänen
    Citation: Fluids and Barriers of the CNS202219:99
    Content type:Research Published on:

  12. Glucose transport from the blood into the brain is tightly regulated by brain microvascular endothelial cells (BMEC), which also use glucose as their primary energy source. To study how BMEC glucose transport ...

    Authors: 卡莉·m·韦伯Bilal Moiz,索菲娅m .珠海维维安a Alpízar Vargas, Andrew Li and Alisa Morss Clyne
    Citation: Fluids and Barriers of the CNS202219:98
    Content type:Research Published on:

  13. Unlike other proteins that exhibit a diffusion pattern after intracerebral injection, laminin displays a vascular pattern. It remains unclear if this unique vascular pattern is caused by laminin-receptor inter...

    Authors: Jingsong Ruan, Karen K. McKee, Peter D. Yurchenco and Yao Yao
    Citation: Fluids and Barriers of the CNS202219:97
    Content type:Research Published on:

  14. A reduced amyloid-β (Aβ)42/40 peptide ratio in blood plasma represents a peripheral biomarker of the cerebral amyloid pathology observed in Alzheimer’s disease brains. The magnitude of the measurable effect in...

    Authors: Hans-Wolfgang Klafki, Barbara Morgado, Oliver Wirths, Olaf Jahn, Chris Bauer, Hermann Esselmann, Johannes Schuchhardt and Jens Wiltfang
    Citation: Fluids and Barriers of the CNS202219:96
    Content type:Research Published on:

  15. Hydrocephalus is characterized by abnormal accumulation of cerebrospinal fluid in the cerebral ventricles and causes motor impairments. The mechanisms underlying the motor changes remain elusive. Enlargement o...

    Authors: Li-Jin Chen, Jeng-Rung Chen and Guo-Fang Tseng
    Citation: Fluids and Barriers of the CNS202219:95
    Content type:Research Published on:

  16. Cerebral aneurysms are more likely to form at bifurcations in the vasculature, where disturbed fluid is prevalent due to flow separation at sufficiently high Reynolds numbers. While previous studies have demon...

    Authors: Nesrine Bouhrira, Brandon J. DeOre, Kiet A. Tran and Peter A. Galie
    Citation: Fluids and Barriers of the CNS202219:94
    Content type:Research Published on:

  17. Disruption of brain barriers is considered to be involved in the pathogenesis of neuronal surface antibody-associated autoimmune encephalitis (NSAE), but few studies have focused on their relationship. We aime...

    Authors: Qi-Lun Lai, Meng-Ting Cai, Yang Zheng, Gao-Li Fang, Bing-Qing Du, Chun-Hong Shen, Jia-Jia Wang, Qin-Jie Weng and Yin-Xi Zhang
    Citation: Fluids and Barriers of the CNS202219:93
    Content type:Research Published on:

  18. Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals. Folate transport...

    Authors: Vishal Sangha, Md. Tozammel Hoque, Jeffrey T. Henderson and Reina Bendayan
    Citation: Fluids and Barriers of the CNS202219:92
    Content type:Brief Report Published on:

  19. Authors: Yong Zhang, Sabrina Rahman Archie, Yashwardhan Ghanwatkar, Sejal Sharma, Saeideh Nozohouri, Elizabeth Burks, Alexander Mdzinarishvili, Zijuan Liu and Thomas J. Abbruscato
    Citation: Fluids and Barriers of the CNS202219:91
    Content type:Correction Published on:

    Theoriginal articlewas published inFluids and Barriers of the CNS202219:46

  20. Apparent permeability of the blood brain barrier to hydrophilic markers has been shown to be higher in the developing brain. Apart from synthesis in situ,any substance detected in the brain parenchyma can origin...

    Authors: Fiona Qiu, Yifan Huang, Norman R. Saunders, Mark D. Habgood and Katarzyna M. Dziegielewska
    Citation: Fluids and Barriers of the CNS202219:90
    Content type:Research Published on:

  21. 特发性正常压力脑积水(iNPH)a multifactorial disease presenting with a classical symptom triad of cognitive decline, gait disturbance and urinary incontinence. The symptoms can be allevi...

    Authors: Jani Sirkka, Laura Säisänen, Petro Julkunen, Mervi Könönen, Elisa Kallioniemi, Ville Leinonen and Nils Danner
    Citation: Fluids and Barriers of the CNS202219:89
    Content type:Research Published on:

  22. While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have d...

    Authors: Maria Vargas-Soria, Juan Jose Ramos-Rodriguez, Angel del Marco, Carmen Hierro-Bujalance, Maria Jose Carranza-Naval, Maria Calvo-Rodriguez, Susanne J. van Veluw, Alan W. Stitt, Rafael Simó, Brian J. Bacskai, Carmen Infante-Garcia and Monica Garcia-Alloza
    Citation: Fluids and Barriers of the CNS202219:88
    Content type:Research Published on:

  23. The blood–brain barrier (BBB) plays a pivotal role in brain health and disease. In the BBB, brain microvascular endothelial cells (BMECs) are connected by tight junctions which regulate paracellular transport,...

    Authors: Raleigh M. Linville, Matthew B. Sklar, Gabrielle N. Grifno, Renée F. Nerenberg, Justin Zhou, Robert Ye, Jackson G. DeStefano, Zhaobin Guo, Ria Jha, John J. Jamieson, Nan Zhao and Peter C. Searson
    Citation: Fluids and Barriers of the CNS202219:87
    Content type:Research Published on:

  25. Intracranial pressure (ICP) has been thought to vary diurnally. This study evaluates diurnal ICP measurements and quantifies changes in ICP occurring with changes in body posture in active idiopathic intracran...

    Authors: James L Mitchell, Rebecca Buckham, Hannah Lyons, Jessica K Walker, Andreas Yiangou, Matilde Sassani, Mark Thaller, Olivia Grech, Zerin Alimajstorovic, Marianne Julher, Georgios Tsermoulas, Kristian Brock, Susan P Mollan and Alexandra J Sinclair
    Citation: Fluids and Barriers of the CNS202219:85
    Content type:Research Published on:

  27. Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lazarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien and Carine Ali
    Citation: Fluids and Barriers of the CNS202219:83
    Content type:Correction Published on:

    Theoriginal articlewas published inFluids and Barriers of the CNS202219:80

  28. Impaired cerebrospinal fluid (CSF) dynamics may contribute to the pathophysiology of neurodegenerative diseases, and play a crucial role in brain health in older people; nonetheless, such age-related changes h...

    Authors: Yosuke Hidaka, Mamoru Hashimoto, Takashi Suehiro, Ryuji Fukuhara, Tomohisa Ishikawa, Naoko Tsunoda, Asuka Koyama, Kazuki Honda, Yusuke Miyagawa, Kazuhiro Yoshiura, Shuken Boku, Kazunari Ishii, Manabu Ikeda and Minoru Takebayashi
    Citation: Fluids and Barriers of the CNS202219:82
    Content type:Research Published on:

  29. Bacterial meningitis is a life-threatening disease that occurs when pathogens such asNeisseria meningitidiscross the meningeal blood cerebrospinal fluid barrier (mBCSFB) and infect the meninges. Due to the huma...

    Authors: Leo M. Endres, Marvin Jungblut, Mustafa Divyapicigil, Markus Sauer, Christian Stigloher, Myron Christodoulides, Brandon J. Kim and Alexandra Schubert-Unkmeir
    Citation: Fluids and Barriers of the CNS202219:81
    Content type:Research Published on:

  30. In the vascular compartment, the serine protease tissue-type plasminogen activator (tPA) promotes fibrinolysis, justifying its clinical use against vasculo-occlusive diseases. Accumulating evidence shows that ...

    Authors: Vincent Zuba, Jonathane Furon, Mathys Bellemain-Sagnard, Sara Martinez de Lizarrondo, Laurent Lebouvier, Marina Rubio, Yannick Hommet, Maxime Gauberti, Denis Vivien and Carine Ali
    Citation: Fluids and Barriers of the CNS202219:80
    Content type:Research Published on:

    TheCorrection to this articlehas been published inFluids and Barriers of the CNS202219:83

  31. The blood brain barrier (BBB) limits the therapeutic perspective for central nervous system (CNS) disorders. Previously we found an anti-mouse transferrin receptor (TfR) VHH (Nb62) that was able to deliver a b...

    Authors: Yessica Wouters, Tom Jaspers, Laura Rué, Lutgarde Serneels, Bart De Strooper and Maarten Dewilde
    Citation: Fluids and Barriers of the CNS202219:79
    Content type:Research Published on:

  32. The composition of tissue obstructing neuroprosthetic devices is largely composed of inflammatory cells with a significant astrocyte component. In a first-of-its-kind study, we profile the astrocyte phenotypes...

    Authors: Fatemeh Khodadadei, Rooshan Arshad, Diego M. Morales, Jacob Gluski, Neena I. Marupudi, James P. McAllister II, David D. Limbrick Jr. and Carolyn A. Harris
    Citation: Fluids and Barriers of the CNS202219:78
    Content type:Research Published on:

  33. The hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated se...

    Authors: Yajuan Shi, Hyosung Kim, Catherine A. Hamann, Elizabeth M. Rhea, Jonathan M. Brunger and Ethan S. Lippmann
    Citation: Fluids and Barriers of the CNS202219:77
    Content type:Research Published on:

  34. Mucopolysaccharidoses comprise a set of genetic diseases marked by an enzymatic dysfunction in the degradation of glycosaminoglycans in lysosomes. There are eight clinically distinct types of mucopolysaccharid...

    Authors: Onur Sahin, Hannah P. Thompson, Grant W. Goodman, Jun Li and Akihiko Urayama
    Citation: Fluids and Barriers of the CNS202219:76
    Content type:Review Published on:

  36. The short and long-term health effects of JUUL electronic cigarette (e-Cig) are largely unknown and warrant extensive research. We hypothesized that JUUL exposure could cause cerebrovascular toxicities impacti...

    Authors: Ali Ehsan Sifat, Sabrina Rahman Archie, Saeideh Nozohouri, Heidi Villalba, Yong Zhang, Sejal Sharma, Yashwardhan Ghanwatkar, Bhuvaneshwar Vaidya, David Mara, Luca Cucullo and Thomas J. Abbruscato
    Citation: Fluids and Barriers of the CNS202219:74
    Content type:Research Published on:

  38. Systemic drug delivery to the central nervous system is limited by presence of the blood–brain barrier (BBB). Low intensity focused ultrasound (LiFUS) is a non-invasive technique to disrupt the BBB, though the...

    Authors: Tasneem A. Arsiwala, Samuel A. Sprowls, Kathryn E. Blethen, Ross A. Fladeland, Cullen P. Wolford, Brooke N. Kielkowski, Morgan J. Glass, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Manish Ranjan, Victor Finomore, Ali Rezai and Paul R. Lockman
    Citation: Fluids and Barriers of the CNS202219:72
    Content type:Research Published on:

  39. 特发性正常压力脑积水(iNPH)a clinico-radiological syndrome of elderly individuals likely sustained by different neurodegenerative changes as copathologies. Since iNPH is a potentially r...

    Authors: Giulia Giannini, Simone Baiardi, Sofia Dellavalle, Corrado Zenesini, Sabina Cevoli, Nils Danner, Henna-Kaisa Jyrkkänen, Marcello Rossi, Barbara Polischi, Corinne Quadalti, Camilla Stefanini, Pietro Cortelli, David Milletti, Sanna-Kaisa Herukka, Giorgio Palandri, Ville Leinonen…
    Citation: Fluids and Barriers of the CNS202219:71
    Content type:Research Published on:

  40. Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose. In this study, we hypothesized that N-methyl-D-aspartate (NMDA)...

    Authors: Kyu-Sung Kim, Min Tae Jeon, Eun Seon Kim, Chan Hee Lee and Do-Geun Kim
    Citation: Fluids and Barriers of the CNS202219:70
    Content type:Research Published on:

  41. A range of neurological pathologies may lead to secondary hydrocephalus. Treatment has largely been limited to surgical cerebrospinal fluid (CSF) diversion, as specific and efficient pharmacological options ar...

    Authors: Trine L. Toft-Bertelsen, Dagne Barbuskaite, Eva Kjer Heerfordt, Sara Diana Lolansen, Søren Norge Andreassen, Nina Rostgaard, Markus Harboe Olsen, Nicolas H. Norager, Tenna Capion, Martin Fredensborg Rath, Marianne Juhler and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS202219:69
    Content type:Research Published on:

  42. The aims of the study were to measure the cerebrospinal fluid (CSF) volumes in the lateral ventricle, high-convexity subarachnoid space, and Sylvian fissure region in patients with idiopathic normal-pressure h...

    Authors: Jaehwan Han, Myoung Nam Kim, Ho-Won Lee, Shin Young Jeong, Sang-Woo Lee, Uicheul Yoon and Kyunghun Kang
    Citation: Fluids and Barriers of the CNS202219:66
    Content type:Research Published on:

  43. In myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), several areas of demyelination are detectable in mouse cerebral cortex, where neuroinflammation events are ...

    Authors: Mariella Errede, Tiziana Annese, Valentina Petrosino, Giovanna Longo, Francesco Girolamo, Ignazio de Trizio, Antonio d’Amati, Antonio Uccelli, Nicole Kerlero de Rosbo and Daniela Virgintino
    Citation: Fluids and Barriers of the CNS202219:68
    Content type:Research Published on:

  44. The pressure difference between the eye and brain in upright postures may be affected by compartmentalization of the optic nerve subarachnoid space (ONSAS). Both pressure and deformation will depend on the mic...

    Authors: Petter Holmlund, Karen-Helene Støverud and Anders Eklund
    Citation: Fluids and Barriers of the CNS202219:67
    Content type:Research Published on:

  45. Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast clinical challenge. Nevertheless, the details underlying the molecular...

    Authors: Eva K. Oernbo, Annette B. Steffensen, Pooya Razzaghi Khamesi, Trine L. Toft-Bertelsen, Dagne Barbuskaite, Frederik Vilhardt, Niklas J. Gerkau, Katerina Tritsaris, Anja H. Simonsen, Sara D. Lolansen, Søren N. Andreassen, Steen G. Hasselbalch, Thomas Zeuthen, Christine R. Rose, Vartan Kurtcuoglu and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS202219:65
    Content type:Research Published on:

  46. Endothelial cells (ECs) in cerebral vessels are considered the primary targets in acute hemorrhagic brain injuries. EC dysfunction can aggravate neuronal injuries by causing secondary inflammatory responses an...

    Authors: Min Joung Lee, Jiebo Zhu, Jong Hun An, Seong Eun Lee, Tae Yeon Kim, Eungseok Oh, Yea Eun Kang, Woosuk Chung and Jun Young Heo
    Citation: Fluids and Barriers of the CNS202219:64
    Content type:Research Published on:

  47. COVID-19, which is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), has resulted in devastating morbidity and mortality worldwide due to lethal pneumonia and respiratory distress. In ad...

    Authors: Daniel Adesse, Luis Gladulich, Liandra Alvarez-Rosa, Michele Siqueira, Anne Caroline Marcos, Marialice Heider, Caroline Soares Motta, Silvia Torices, Michal Toborek and Joice Stipursky
    Citation: Fluids and Barriers of the CNS202219:63
    Content type:Review Published on:

  48. Posthemorrhagic hydrocephalus (PHH) often develops following hemorrhagic events such as intraventricular hemorrhage (IVH) and subarachnoid hemorrhage (SAH). Treatment is limited to surgical diversion of the ce...

    Authors: Sara Diana Lolansen, Nina Rostgaard, Dagne Barbuskaite, Tenna Capion, Markus Harboe Olsen, Nicolas H. Norager, Frederik Vilhardt, Søren Norge Andreassen, Trine L. Toft-Bertelsen, Fenghui Ye, Marianne Juhler, Richard F. Keep and Nanna MacAulay
    Citation: Fluids and Barriers of the CNS202219:62
    Content type:Research Published on:

  49. Infectious and immunological theories of schizophrenia have been discussed for over a century. Contradictory results for infectious agents in association with schizophrenia spectrum disorders (SSDs) were repor...

    Authors: Kimon Runge, Agnes Balla, Bernd L. Fiebich, Simon J. Maier, Benjamin Pankratz, Andrea Schlump, Kathrin Nickel, Rick Dersch, Katharina Domschke, Ludger Tebartz van Elst and Dominique Endres
    Citation: Fluids and Barriers of the CNS202219:61
    Content type:Research Published on:

  50. Extracellular vesicles (EVs) are particles naturally released from cells that are delimited by a lipid bilayer and are unable to replicate. How the EVs cross the Blood–Brain barrier (BBB) in a bidirectional ma...

    Authors: Héctor M. Ramos-Zaldívar, Iva Polakovicova, Edison Salas-Huenuleo, Alejandro H. Corvalán, Marcelo J. Kogan, Claudia P. Yefi and Marcelo E. Andia
    Citation: Fluids and Barriers of the CNS202219:60
    Content type:Review Published on:
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  • ISSN: 2045-8118 (electronic)

Fluids and Barriers of the CNS

ISSN: 2045-8118